Cutting edge: IL-4 receptor expression by non-bone marrow-derived cells is required to expel gastrointestinal nematode parasites.
J Immunol
; 167(11): 6078-81, 2001 Dec 01.
Article
in En
| MEDLINE
| ID: mdl-11714764
ABSTRACT
Expulsion of two gastrointestinal nematode parasites, Nippostrongylus brasiliensis and Trichinella spiralis, is similar in that both require IL-4Ralpha expression, but different in that T cells and mast cells are required for IL-4-induced expulsion of T. spiralis but not N. brasiliensis. To examine the role of IL-4Ralpha signaling in immunity to these parasites, we studied worm expulsion in chimeric mice that selectively expressed IL-4Ralpha on bone marrow-derived or non-bone marrow-derived cells. N. brasiliensis was expelled by mice that expressed IL-4Ralpha only on non-bone marrow-derived cells, but not by mice that expressed IL-4Ralpha only on bone marrow-derived cells. Although T. spiralis expulsion required IL-4Ralpha expression by both bone marrow- and non-bone marrow-derived cells, IL-4 stimulation eliminated the requirement for IL-4Ralpha expression by bone marrow-derived cells. Thus, direct IL-4Ralpha signaling of nonimmune gastrointestinal cells may be generally required to induce worm expulsion, even when mast cell and T cell responses are also required.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bone Marrow Cells
/
T-Lymphocytes
/
Trichinella spiralis
/
Receptors, Interleukin-4
/
Gastrointestinal Diseases
/
Mast Cells
/
Nippostrongylus
Limits:
Animals
Language:
En
Journal:
J Immunol
Year:
2001
Document type:
Article
Affiliation country:
United States