A temporary phosphorus tether/ring-closing metathesis strategy to functionalized 1,4-diamines.
Org Lett
; 3(24): 3939-42, 2001 Nov 29.
Article
in En
| MEDLINE
| ID: mdl-11720574
ABSTRACT
The synthesis of 1,4-diamines containing the (Z)-1,4-diaminobut-2-ene subunit via a temporary phosphorus tether/RCM strategy is described. We have developed a new method utilizing phosphorus nuclei as suitable temporary tethers for the coupling of nonracemic allylic amines. This approach allows for the generation of C(2)-symmetric and unsymmetric 1,4-diamines 1-3, which may have considerable synthetic and biological utility. This represents the first synthetic pathway for the expedient coupling of two amines via a temporary tether approach. [structure see text]
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phosphorus
/
Diamines
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2001
Document type:
Article
Affiliation country:
United States