(1R,3S)-1-Aminocyclopentane-1,3-dicarboxylic acid (RS-ACPD) reduces intracellular glutamate levels in astrocytes.

Ye, Z C; Ransom, B R; Sontheimer, H

Ye, Z C; Ransom, B R; Sontheimer, H.

Affiliation

Ye ZC; Department of Neurology, University of Washington, Seattle, Washington, USA.

J Neurochem ; 79(4): 756-66, 2001 Nov.

Article in En | MEDLINE | ID: mdl-11723168

Subject(s)

Astrocytes/metabolism; Cycloleucine/pharmacology; Glutamic Acid/metabolism; Intracellular Fluid/metabolism; Neuroprotective Agents/pharmacology; Animals; Astrocytes/cytology; Astrocytes/drug effects; Biological Transport/drug effects; Cell Size/drug effects; Cells, Cultured; Cycloleucine/analogs & derivatives; Enzyme Inhibitors/pharmacology; Glutaminase/antagonists & inhibitors; Hippocampus/cytology; Hippocampus/drug effects; Hippocampus/metabolism; Molecular Conformation; Potassium/metabolism; Rats; Rats, Sprague-Dawley; Sodium/metabolism; Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors

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Collection: 01-internacional Database: MEDLINE Main subject: Astrocytes / Neuroprotective Agents / Glutamic Acid / Cycloleucine / Intracellular Fluid Limits: Animals Language: En Journal: J Neurochem Year: 2001 Document type: Article Affiliation country: United States Country of publication: United kingdom

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