A new bis-indole, KARs, induces selective M arrest with specific spindle aberration in neuroblastoma cell line SH-SY5Y.

Comín-Anduix, B; Agell, N; Bachs, O; Ovádi, J; Cascante, M

Comín-Anduix, B; Agell, N; Bachs, O; Ovádi, J; Cascante, M.

Affiliation

Comín-Anduix B; Department of Biochemistry and Molecular Biology, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Faculty of Chemistry, University of Barcelona, Barcelona, Spain.

Mol Pharmacol ; 60(6): 1235-42, 2001 Dec.

Article in En | MEDLINE | ID: mdl-11723230

Subject(s)

Antineoplastic Agents, Phytogenic/pharmacology; G2 Phase/drug effects; Mitosis/drug effects; Neuroblastoma/pathology; Spindle Apparatus/drug effects; Vinblastine/analogs & derivatives; Apoptosis; CDC2 Protein Kinase/drug effects; CDC2 Protein Kinase/metabolism; Cell Division/drug effects; Chromosomes/drug effects; Cyclin A/drug effects; Cyclin A/metabolism; Cyclin B/drug effects; Cyclin B/metabolism; Cyclin B1; Humans; Interphase/drug effects; Microtubules/drug effects; Tumor Cells, Cultured; Vinblastine/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Vinblastine / G2 Phase / Mitosis / Spindle Apparatus / Neuroblastoma / Antineoplastic Agents, Phytogenic Limits: Humans Language: En Journal: Mol Pharmacol Year: 2001 Document type: Article Affiliation country: Spain Country of publication: United States

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