Cortisol feedback during the HPA quiescent period in patients with major depression.
Am J Psychiatry
; 158(12): 2083-5, 2001 Dec.
Article
in En
| MEDLINE
| ID: mdl-11729034
ABSTRACT
OBJECTIVE:
The authors tested the hypothesis that patients with major depression have a defect in the mechanism by which cortisol exerts negative feedback on the hypothalamic-pituitary-adrenal (HPA) axis during the HPA axis quiescent period.METHOD:
Twenty-nine patients with major depression and 25 healthy comparison subjects were randomly assigned to administration of 15 mg cortisol or placebo infused over 2 hours beginning at 700 p.m. Cortisol and ACTH levels were measured at baseline and every 30 minutes from 730 p.m. to 1100 p.m.RESULTS:
Differences between the patients and the comparison subjects in the ACTH response to the cortisol infusion, relative to the ACTH response to placebo, were not found.CONCLUSIONS:
The results provide some evidence that patients with major depression do not have an abnormality of cortisol feedback during the HPA axis quiescent period.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pituitary-Adrenal System
/
Hydrocortisone
/
Depressive Disorder, Major
/
Hypothalamo-Hypophyseal System
Type of study:
Clinical_trials
/
Diagnostic_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Am J Psychiatry
Year:
2001
Document type:
Article
Affiliation country:
United States