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Identification of two putative ATP-cassette genes in Encephalitozoon intestinalis.
Bonafonte, M T; Stewart, J; Mead, J R.
Affiliation
  • Bonafonte MT; Medical Research 151, Veterans Affairs Medical Center, 1670 Clairmont Road, Decatur, GA 30033, USA.
Int J Parasitol ; 31(14): 1681-5, 2001 Dec.
Article in En | MEDLINE | ID: mdl-11730796
ABSTRACT
Currently existing chemotherapeutic compounds are limited and few are effective for treating microsporidiosis. It is possible that resistance of Encephalitozoon to some drugs occurs by efflux mechanisms similar to those previously described for mammalian tumour cells, bacteria or protozoal parasites such as Plasmodium, Leishmania and Entamoeba histolytica. The data in the present study suggest that Encephalitozoon intestinalis contains at least one multidrug resistance gene. We report here two complete sequences EiABC1 and EiABC2, encoding different ATP-binding cassette genes from E. intestinalis, including a P-gp.
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Collection: 01-internacional Database: MEDLINE Main subject: Protozoan Proteins / DNA, Protozoan / Encephalitozoon / ATP-Binding Cassette Transporters Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Int J Parasitol Year: 2001 Document type: Article Affiliation country: United States
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Collection: 01-internacional Database: MEDLINE Main subject: Protozoan Proteins / DNA, Protozoan / Encephalitozoon / ATP-Binding Cassette Transporters Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Int J Parasitol Year: 2001 Document type: Article Affiliation country: United States