Spirocyclic restriction of nucleosides. An analysis of protecting group feasibility while accessing prototype anti-1-oxaspiro[4.4]nonanyl mimics.
Org Lett
; 3(25): 4043-5, 2001 Dec 13.
Article
in En
| MEDLINE
| ID: mdl-11735580
ABSTRACT
[reaction see text] The first spirocyclic nucleoside featuring a beta-hydroxyl (anti) at C5' has yielded to synthesis. While the OMOM functionality proved to be sensitive to the conditions necessary to incorporate heterocyclic bases, PMB protection of the carbinol was readily accommodated. The remarkably similar minimum-energy conformations of the title compounds relative to natural thymidine as deduced by Amber calculations in the gas phase are noted.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
DNA
/
Nucleosides
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2001
Document type:
Article
Affiliation country:
United States