Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces.

Feng, R; Rampon, C; Tang, Y P; Shrom, D; Jin, J; Kyin, M; Sopher, B; Miller, M W; Ware, C B; Martin, G M; Kim, S H; Langdon, R B; Sisodia, S S; Tsien, J Z

Feng, R; Rampon, C; Tang, Y P; Shrom, D; Jin, J; Kyin, M; Sopher, B; Miller, M W; Ware, C B; Martin, G M; Kim, S H; Langdon, R B; Sisodia, S S; Tsien, J Z.

Affiliation

Feng R; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.

Neuron ; 32(5): 911-26, 2001 Dec 06.

Article in En | MEDLINE | ID: mdl-11738035

Subject(s)

Amyloid beta-Protein Precursor/analogs & derivatives; Hippocampus/growth & development; Membrane Proteins/deficiency; Membrane Proteins/genetics; Memory/physiology; Prosencephalon/growth & development; Alzheimer Disease/genetics; Amyloid beta-Protein Precursor/metabolism; Animals; Brain Chemistry/genetics; Electrophysiology; Hippocampus/pathology; Memory Disorders/genetics; Memory Disorders/pathology; Memory Disorders/physiopathology; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Mice, Transgenic; Neurons/pathology; Presenilin-1; Prosencephalon/pathology; RNA, Messenger/genetics; RNA, Messenger/metabolism

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Prosencephalon / Amyloid beta-Protein Precursor / Hippocampus / Membrane Proteins / Memory Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Neuron Journal subject: NEUROLOGIA Year: 2001 Document type: Article Affiliation country: United States Country of publication: United States

Search on Google

Add to My VHL

XML

PubMed Links