Synthesis and biological evaluation of new 4-arylpiperidines and 4-aryl-4-piperidinols: dual Na(+) and Ca(2+) channel blockers with reduced affinity for dopamine D(2) receptors.

Annoura, Hirokazu; Nakanishi, Kyoko; Uesugi, Mayumi; Fukunaga, Atsuko; Imajo, Seiichi; Miyajima, Atsuko; Tamura-Horikawa, Yoshiko; Tamura, Shigeki

Annoura, Hirokazu; Nakanishi, Kyoko; Uesugi, Mayumi; Fukunaga, Atsuko; Imajo, Seiichi; Miyajima, Atsuko; Tamura-Horikawa, Yoshiko; Tamura, Shigeki.

Affiliation

Annoura H; Suntory Biomedical Research Limited, 1-1-1, Wakayamadai, Shimamoto-cho, Mishima-gun, 618-8503, Osaka, Japan. hirokazu_annoura@suntory.co.jp

Bioorg Med Chem ; 10(2): 371-83, 2002 Feb.

Article in En | MEDLINE | ID: mdl-11741786

Subject(s)

Calcium Channel Blockers/chemistry; Calcium Channel Blockers/pharmacology; Phenyl Ethers/chemistry; Phenyl Ethers/pharmacology; Piperidines/chemistry; Piperidines/pharmacology; Receptors, Dopamine D2/metabolism; Sodium Channel Blockers/chemistry; Sodium Channel Blockers/pharmacology; Animals; Biochemistry/methods; Calcium Channel Blockers/metabolism; Cerebral Cortex/drug effects; Cerebral Cortex/metabolism; Drug Evaluation, Preclinical; Female; Flunarizine/chemistry; Flunarizine/pharmacology; Ischemia/drug therapy; Male; Mice; Mice, Inbred DBA; Neuroprotective Agents/chemistry; Neuroprotective Agents/metabolism; Neuroprotective Agents/pharmacology; Rats; Rats, Wistar; Receptors, Dopamine D2/drug effects; Seizures/drug therapy; Sodium Channel Blockers/metabolism; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Phenyl Ethers / Piperidines / Calcium Channel Blockers / Receptors, Dopamine D2 / Sodium Channel Blockers Type of study: Evaluation_studies Limits: Animals Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2002 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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