Increased endothelin-1 in colorectal cancer and reduction of tumour growth by ET(A) receptor antagonism.

Asham, E; Shankar, A; Loizidou, M; Fredericks, S; Miller, K; Boulos, P B; Burnstock, G; Taylor, I

Asham, E; Shankar, A; Loizidou, M; Fredericks, S; Miller, K; Boulos, P B; Burnstock, G; Taylor, I.

Affiliation

Asham E; Departments of Surgery, Histopathology, The Royal Free and University College Medical School, 67-73 Riding House Street, London, UK.

Br J Cancer ; 85(11): 1759-63, 2001 Nov 30.

Article in En | MEDLINE | ID: mdl-11742499

Subject(s)

Colorectal Neoplasms/prevention & control; Endothelin Receptor Antagonists; Endothelin-1/drug effects; Peptides, Cyclic/pharmacology; Adult; Aged; Aged, 80 and over; Animals; Colon/drug effects; Colon/metabolism; Colon/pathology; Colorectal Neoplasms/blood; Colorectal Neoplasms/pathology; Endothelin-1/blood; Endothelin-1/metabolism; Female; Humans; Immunohistochemistry; Liver Neoplasms/blood; Liver Neoplasms/secondary; Male; Middle Aged; Neoplasm Transplantation; Neoplasms, Experimental/blood; Neoplasms, Experimental/pathology; Neoplasms, Experimental/prevention & control; Oligopeptides/pharmacology; Oligopeptides/therapeutic use; Peptides, Cyclic/therapeutic use; Pyrrolidines/pharmacology; Pyrrolidines/therapeutic use; Rats; Receptor, Endothelin A; Receptor, Endothelin B

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides, Cyclic / Colorectal Neoplasms / Endothelin-1 / Endothelin Receptor Antagonists Limits: Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Language: En Journal: Br J Cancer Year: 2001 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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