Gaucher disease with pulmonary involvement in a 6-year-old girl: report of resolution of radiographic abnormalities on increasing dose of imiglucerase.
J Pediatr
; 139(6): 862-4, 2001 Dec.
Article
in En
| MEDLINE
| ID: mdl-11743514
ABSTRACT
We report resolution of ground-glass appearance in high-resolution computed tomography of chest in a 6-year-old girl who had Gaucher disease with pulmonary involvement. This radiographic abnormality, which developed during the course of enzyme replacement therapy at doses between 20 to 60 U/kg/2 weeks, resolved when the dose was increased to 100 U/kg/2 weeks. This case illustrates the importance of trial of escalating dosage in the face of failure of response at lower doses.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gaucher Disease
/
Glucosylceramidase
/
Lung Diseases
Type of study:
Diagnostic_studies
Limits:
Child
/
Female
/
Humans
Language:
En
Journal:
J Pediatr
Year:
2001
Document type:
Article
Affiliation country:
Hong Kong