Cognitive correlates of human brain aging: a quantitative magnetic resonance imaging investigation.
J Neuropsychiatry Clin Neurosci
; 13(4): 471-85, 2001.
Article
in En
| MEDLINE
| ID: mdl-11748316
ABSTRACT
The relations between age-related changes in brain structure and neuropsychological test performance in 320 elderly nonclinical volunteers (ages 66-90) were examined by using quantitative MRI data and measures of attention, information processing speed, language, memory, and visuospatial ability. Final path analyses revealed significant brain-behavior relationships for two of the six cognitive measures:
the Trail Making Test part B and visual delayed memory. Poorer performance on Trails B was associated with smaller cerebral hemisphere volumes and larger volumes of peripheral CSF, lateral ventricles, and third ventricle. Poorer recall on visual delayed memory was associated with larger volumes of the lateral ventricles and third ventricle. The findings demonstrate a relationship between age-related changes in brain structure and an age-related decline in attention, psychomotor speed, and visual delayed memory. The neurobiological basis for this relationship requires further investigation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain
/
Aging
/
Magnetic Resonance Imaging
/
Neuropsychological Tests
Type of study:
Clinical_trials
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
En
Journal:
J Neuropsychiatry Clin Neurosci
Journal subject:
NEUROLOGIA
/
PSIQUIATRIA
Year:
2001
Document type:
Article
Affiliation country:
United States