Effect of methylprednisolone on phospholipase A(2) activity and lung surfactant degradation in acute lung injury in rabbits.

Kuwabara, K; Furue, S; Tomita, Y; Ueno, M; Ono, T; Matsukawa, A; Yoshinaga, M; Mikawa, K; Nishina, K; Shiga, M; Obara, H; Hori, Y

Kuwabara, K; Furue, S; Tomita, Y; Ueno, M; Ono, T; Matsukawa, A; Yoshinaga, M; Mikawa, K; Nishina, K; Shiga, M; Obara, H; Hori, Y.

Affiliation

Kuwabara K; Discovery Research Laboratories, Division of Pharmacology, Shionogi & Co., Ltd., 3-1-1, Futaba-cho, Toyonaka, Osaka 561-0825, Japan.

Eur J Pharmacol ; 433(2-3): 209-16, 2001 Dec 21.

Article in En | MEDLINE | ID: mdl-11755154

Subject(s)

Lung/drug effects; Methylprednisolone/pharmacology; Phospholipases A/metabolism; Pulmonary Surfactants/metabolism; Respiratory Distress Syndrome/prevention & control; Animals; Bronchoalveolar Lavage Fluid/chemistry; Bronchoalveolar Lavage Fluid/cytology; Capillary Permeability/drug effects; Eicosanoids/analysis; Interleukin-8/blood; Lung/metabolism; Lung/pathology; Male; Oleic Acid; Rabbits; Respiratory Distress Syndrome/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Phospholipases A / Respiratory Distress Syndrome / Pulmonary Surfactants / Methylprednisolone / Lung Type of study: Prognostic_studies Limits: Animals Language: En Journal: Eur J Pharmacol Year: 2001 Document type: Article Affiliation country: Japan Country of publication: Netherlands

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