Ectopic osteogenesis with biphasic ceramics of hydroxyapatite and tricalcium phosphate in rabbits.
Biomaterials
; 23(2): 407-12, 2002 Jan.
Article
in En
| MEDLINE
| ID: mdl-11761160
ABSTRACT
Porous calcium phosphate ceramics consisting of hydroxyapatite (HA) and tricalcium phosphate (TCP) with different HA to TCP ratio were implanted intramuscularly in rabbits for six months in order to carry out a comparative study on osteogenic activity of the ceramics. Bone formation was detected only in HT73 (HA to TCP ratio, 7-3) specimens. Other implants, HT28 (2-8) and HT010 (0-10), could not induce bone. After a six-month period of implantation, HT28 and HT010 implants showed obvious degradation of the implants changing their shape and size macro and microscopically. Microscopically, they showed aggregates of fine particles and appearance of multinucleated cells. However, HT73 implants was less degraded and could maintain their original structure macro and microscopically. This study showed that HT73 ceramics can induce bone in rabbit muscle tissue and it is considered that maintenance of porous structure, that is, degradation rate of the materials may be one of the affecting factors in ceramic-induced osteogenesis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteogenesis
/
Biocompatible Materials
/
Calcium Phosphates
/
Ceramics
/
Hydroxyapatites
Limits:
Animals
Language:
En
Journal:
Biomaterials
Year:
2002
Document type:
Article
Affiliation country:
Japan