DEF-1/ASAP1 is a GTPase-activating protein (GAP) for ARF1 that enhances cell motility through a GAP-dependent mechanism.

Furman, Craig; Short, Sarah M; Subramanian, Romesh R; Zetter, Bruce R; Roberts, Thomas M

Furman, Craig; Short, Sarah M; Subramanian, Romesh R; Zetter, Bruce R; Roberts, Thomas M.

Affiliation

Furman C; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

J Biol Chem ; 277(10): 7962-9, 2002 Mar 08.

Article in En | MEDLINE | ID: mdl-11773070

Subject(s)

Adaptor Proteins, Signal Transducing; Carrier Proteins/metabolism; Carrier Proteins/physiology; GTPase-Activating Proteins/metabolism; src Homology Domains; 3T3 Cells; ADP-Ribosylation Factor 1/metabolism; ADP-Ribosylation Factor 6; ADP-Ribosylation Factors/metabolism; Animals; Blotting, Western; COS Cells; Cell Line; Cell Movement; Cell Separation; Cytoskeletal Proteins/biosynthesis; Cytoskeleton/metabolism; DNA, Complementary/metabolism; Dose-Response Relationship, Drug; GTPase-Activating Proteins/chemistry; Glutathione Transferase/metabolism; Humans; Mice; Microscopy, Fluorescence; Paxillin; Phosphoproteins/biosynthesis; Platelet-Derived Growth Factor/metabolism; Protein Binding; Protein Structure, Tertiary; Recombinant Fusion Proteins/metabolism; Retroviridae/metabolism; Time Factors; Transfection; Zinc Fingers

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Collection: 01-internacional Database: MEDLINE Main subject: Carrier Proteins / Src Homology Domains / GTPase-Activating Proteins / Adaptor Proteins, Signal Transducing Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2002 Document type: Article Affiliation country: United States Country of publication: United States

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