The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity.

van Loo, G; van Gurp, M; Depuydt, B; Srinivasula, S M; Rodriguez, I; Alnemri, E S; Gevaert, K; Vandekerckhove, J; Declercq, W; Vandenabeele, P

van Loo, G; van Gurp, M; Depuydt, B; Srinivasula, S M; Rodriguez, I; Alnemri, E S; Gevaert, K; Vandekerckhove, J; Declercq, W; Vandenabeele, P.

Affiliation

van Loo G; Flanders Interuniversity Institute for Biotechnology and Ghent University, Molecular Signalling and Cell Death Unit, Department of Molecular Biology, K.L. Ledeganckstraat 35, B-9000 Ghent, Belgium.

Cell Death Differ ; 9(1): 20-6, 2002 Jan.

Article in En | MEDLINE | ID: mdl-11803371

Subject(s)

Apoptosis/physiology; Caspases/metabolism; Mitochondria/metabolism; Proteins/metabolism; Serine Endopeptidases/metabolism; Amino Acid Sequence; Animals; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins/pharmacology; Cells, Cultured; Cytosol/metabolism; Enzyme Activation; High-Temperature Requirement A Serine Peptidase 2; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondrial Proteins; Molecular Sequence Data; Translocation, Genetic/drug effects; X-Linked Inhibitor of Apoptosis Protein

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Collection: 01-internacional Database: MEDLINE Main subject: Serine Endopeptidases / Proteins / Apoptosis / Caspases / Mitochondria Limits: Animals Language: En Journal: Cell Death Differ Year: 2002 Document type: Article Affiliation country: Belgium Country of publication: United kingdom

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