Effects of indole and caffeine on cAMP in the ind1 and cfn1 mutant strains of Schizophyllum commune during sexual development.
FEMS Microbiol Lett
; 206(2): 247-51, 2002 Jan 10.
Article
in En
| MEDLINE
| ID: mdl-11814671
ABSTRACT
The ind1 and cfn1 mutations of Schizophyllum commune express resistance to high concentrations of indole and caffeine respectively, and also affect sexual development. To clarify molecular events caused by the mutations, it was investigated how cAMP levels in S. commune strains respond to externally supplied indole and caffeine. Both compounds increased the cAMP levels in wild-type strains under several culture conditions. During sexual development of the ind1 mutant, the cAMP level in an early stage (hyphal aggregation) was highly increased by addition of indole, and the phenomenon disappeared in a later stage (fruit body formation). For the cfn1 mutants, the incremental increase in cAMP levels by addition of caffeine was smaller than that of wild-type strains.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Schizophyllum
/
Caffeine
/
Cyclic AMP
/
Indoles
Language:
En
Journal:
FEMS Microbiol Lett
Year:
2002
Document type:
Article
Affiliation country:
Japan