A novel monoclonal antibody against the extracellular domain of GPIbbeta modulates vWF mediated platelet adhesion.

Perrault, C; Moog, S; Rubinstein, E; Santer, M; Baas, M J; de la Salle, C; Ravanat, C; Dambach, J; Freund, M; Santoso, S; Cazenave, J P; Lanza, F

Perrault, C; Moog, S; Rubinstein, E; Santer, M; Baas, M J; de la Salle, C; Ravanat, C; Dambach, J; Freund, M; Santoso, S; Cazenave, J P; Lanza, F.

Affiliation

Perrault C; INSERM U.311, Etablissement Français du Sang-Alsace, Strasbourg, France.

Thromb Haemost ; 86(5): 1238-48, 2001 Nov.

Article in En | MEDLINE | ID: mdl-11816713

Subject(s)

Antibodies, Monoclonal/pharmacology; Platelet Adhesiveness/drug effects; Platelet Glycoprotein GPIb-IX Complex/immunology; von Willebrand Factor/pharmacology; Animals; Antibodies, Monoclonal/isolation & purification; Blood Platelets/chemistry; Blood Platelets/drug effects; Blood Platelets/immunology; Drug Interactions; Epitopes/chemistry; Epitopes/immunology; Humans; Male; Mice; Platelet Aggregation/drug effects; Platelet Aggregation Inhibitors/pharmacology; Platelet Glycoprotein GPIb-IX Complex/physiology; Protein Binding/drug effects; Protein Structure, Tertiary; Rats; Species Specificity; von Willebrand Factor/antagonists & inhibitors; von Willebrand Factor/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Von Willebrand Factor / Platelet Adhesiveness / Platelet Glycoprotein GPIb-IX Complex / Antibodies, Monoclonal Limits: Animals / Humans / Male Language: En Journal: Thromb Haemost Year: 2001 Document type: Article Affiliation country: France Country of publication: Germany

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