Pentoxifylline potentiates nitric oxide production in interleukin-1beta-stimulated vascular smooth muscle cells through cyclic AMP-dependent protein kinase A pathway.

Kim, N Y; Pae, H O; Kim, Y C; Choi, C K; Rim, J S; Lee, H S; Kim, Y M; Chung, H T

Kim, N Y; Pae, H O; Kim, Y C; Choi, C K; Rim, J S; Lee, H S; Kim, Y M; Chung, H T.

Affiliation

Kim NY; Department of Microbiology and Immunology, School of Medicine, Wonkwang University, Iksan, 570-749, Chonbuk, South Korea.

Gen Pharmacol ; 35(4): 205-11, 2000 Oct.

Article in En | MEDLINE | ID: mdl-11827727

Subject(s)

Cyclic AMP-Dependent Protein Kinases/physiology; Cyclic AMP/physiology; Interleukin-1/pharmacology; Muscle, Smooth, Vascular/drug effects; Nitric Oxide/biosynthesis; Pentoxifylline/pharmacology; Vasodilator Agents/pharmacology; Animals; Biological Transport/drug effects; Cell Nucleus/metabolism; Cells, Cultured; Cyclic AMP/analysis; Cyclic AMP-Dependent Protein Kinase Type II; Cytoplasm/metabolism; Drug Synergism; Gene Expression Regulation, Enzymologic/drug effects; Muscle, Smooth, Vascular/cytology; Muscle, Smooth, Vascular/metabolism; NF-kappa B/metabolism; Nitric Oxide Synthase/genetics; Nitric Oxide Synthase Type II; Rats; Transcription Factor RelA

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Collection: 01-internacional Database: MEDLINE Main subject: Pentoxifylline / Vasodilator Agents / Interleukin-1 / Cyclic AMP-Dependent Protein Kinases / Cyclic AMP / Muscle, Smooth, Vascular / Nitric Oxide Limits: Animals Language: En Journal: Gen Pharmacol Year: 2000 Document type: Article Affiliation country: South Korea

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