Synthesis and antioxidant properties of some new flavone derivatives on lipid peroxidation in the rat liver.
Pharmazie
; 55(5): 359-61, 2000 May.
Article
in En
| MEDLINE
| ID: mdl-11828615
ABSTRACT
A series of 2'-, 3'-, 4'- and 6-substituted flavone derivatives was synthesized and their in vitro effects on rat liver microsomal NADPH-dependent lipid peroxidation (LP) levels were determined. Retinoic acid, at 10(-4) M concentration, decreased the LP level by about 34%. A significant decrease in male liver microsomal LP level was noted for the compounds 3d, 1a, 3b and 4b at a concentration of 10(-4) M (100%, 95%, 75% and 62%, respectively).
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Flavonoids
/
Lipid Peroxidation
/
Liver
/
Antioxidants
Limits:
Animals
Language:
En
Journal:
Pharmazie
Journal subject:
FARMACIA
Year:
2000
Document type:
Article
Affiliation country:
Turkey