A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF.
Neuron
; 33(3): 383-95, 2002 Jan 31.
Article
in En
| MEDLINE
| ID: mdl-11832226
ABSTRACT
Transcription of the brain-derived neurotrophic factor (BDNF) gene is regulated in a calcium- and neuron-selective manner; however, the mechanisms that underlie this selectivity are not known. We have characterized a new calcium-response element, CaRE1, that is required for activity-dependent transcription of BDNF exon III and have cloned a transcription factor, CaRF, that activates transcription from BDNF promoter III in a CaRE1-dependent manner. The transcriptional activity of CaRF is regulated in a calcium- and neuron-selective manner, suggesting that CaRF may confer selectivity upon the activity-dependent induction of BDNF exon III expression.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Transcription Factors
/
Gene Expression Regulation
/
Brain-Derived Neurotrophic Factor
/
Response Elements
/
Neurons
Limits:
Animals
/
Humans
Language:
En
Journal:
Neuron
Journal subject:
NEUROLOGIA
Year:
2002
Document type:
Article
Affiliation country:
United States