Experimental disseminated candidiasis. II. Administration of glucocorticosteroids, susceptibility to infection, and immunity.
J Infect Dis
; 132(4): 393-8, 1975 Oct.
Article
in En
| MEDLINE
| ID: mdl-1185009
ABSTRACT
A model of experimental disseminated candidiasis in inbred guinea pigs was used for study of the effects of both short-acting and long-acting glucocorticosteroid administration on the susceptibility to infection, the development of in vivo and in vitro parameters of cell-mediated immunity, and the expression of already established Candida-specific, cell-mediated immunity. Results revealed that long-acting glucocorticosteroids markedly potentiated infection, increasing mortality and suppressing already established cellular immune parameters. The development of cellular immunity to Candida was not impaired. Short-acting glucocorticosteroids, however, did not potentiate infection, and they affected neither the development nor the expression of immune parameters.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Candidiasis
/
Cortisone
/
Hydrocortisone
/
Immunity, Cellular
Limits:
Animals
Language:
En
Journal:
J Infect Dis
Year:
1975
Document type:
Article