CD4 independence of simian immunodeficiency virus Envs is associated with macrophage tropism, neutralization sensitivity, and attenuated pathogenicity.

Puffer, Bridget A; Pöhlmann, Stefan; Edinger, Aimee L; Carlin, Dan; Sanchez, Melissa D; Reitter, Julie; Watry, Debbie D; Fox, Howard S; Desrosiers, Ronald C; Doms, Robert W

Puffer, Bridget A; Pöhlmann, Stefan; Edinger, Aimee L; Carlin, Dan; Sanchez, Melissa D; Reitter, Julie; Watry, Debbie D; Fox, Howard S; Desrosiers, Ronald C; Doms, Robert W.

Affiliation

Puffer BA; Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

J Virol ; 76(6): 2595-605, 2002 Mar.

Article in En | MEDLINE | ID: mdl-11861825

Subject(s)

CD4 Antigens/metabolism; Gene Products, env/metabolism; Macrophages/virology; Simian Immunodeficiency Virus/metabolism; Simian Immunodeficiency Virus/pathogenicity; Animals; Antibodies, Viral/immunology; Cell Line; Humans; Macaca mulatta; Neutralization Tests; Receptors, CCR5; Simian Acquired Immunodeficiency Syndrome/immunology; Simian Acquired Immunodeficiency Syndrome/virology; Simian Immunodeficiency Virus/immunology; Virulence

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD4 Antigens / Gene Products, env / Simian Immunodeficiency Virus / Macrophages Type of study: Diagnostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: J Virol Year: 2002 Document type: Article Affiliation country: United States Country of publication: United States

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