All good things must come to an end: how is Notch signaling turned off?
Sci STKE
; 1999(9): PE1, 1999 Nov 23.
Article
in En
| MEDLINE
| ID: mdl-11865186
ABSTRACT
Turning off signaling pathways can be just as important for proper biological regulation as turning them on. The Notch signaling pathway controls development of the nervous system in Drosophila. Proteolysis of Notch appears to initiate signaling, but further proteolysis may also terminate signals from this pathway. Kopan discusses mechanisms that limit signaling by Notch, including recent evidence that degradation of specifically targeted proteins by the proteasome is required.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Signal Transduction
/
Down-Regulation
/
Membrane Proteins
Limits:
Animals
Language:
En
Journal:
Sci STKE
Journal subject:
CIENCIA
/
FISIOLOGIA
Year:
1999
Document type:
Article
Affiliation country:
United States