Testing for antineutrophil cytoplasmic antibodies.
Expert Rev Mol Diagn
; 1(3): 281-9, 2001 Sep.
Article
in En
| MEDLINE
| ID: mdl-11901833
ABSTRACT
The most common reason to request a test for antineutrophil cytoplasmic antibodies (ANCA) is to diagnose Wegener's granulomatosis and microscopic polyangiitis and to monitor inflammatory activity in these diseases. Several retrospective and prospective studies have suggested that the demonstration of ANCA lacks sensitivity and specificity, but these series have detected ANCA with neutrophil-indirect immunofluorescence alone, have used a disease classification that did not describe microscopic polyangiitis and have included patients with inactive disease. The 'International Consensus Statement on Testing and Reporting ANCA' has been developed to optimize the clinical relevance of ANCA testing by the adoption of standardized testing and reporting procedures. International collaborative efforts continue to focus on improving the tests for ANCA.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antibodies, Antineutrophil Cytoplasmic
/
Molecular Diagnostic Techniques
Type of study:
Diagnostic_studies
/
Observational_studies
Limits:
Humans
Language:
En
Journal:
Expert Rev Mol Diagn
Journal subject:
BIOLOGIA MOLECULAR
Year:
2001
Document type:
Article
Affiliation country:
Australia