Enhanced oral bioavailability of docetaxel by coadministration of cyclosporine: quantitation and role of P-glycoprotein.

Chiou, Win L; Wu, Ta Chen; Ma, Chien; Jeong, Hyun Young

Chiou, Win L; Wu, Ta Chen; Ma, Chien; Jeong, Hyun Young.

J Clin Oncol ; 20(7): 1951-2; author reply 1952, 2002 Apr 01.

Article in En | MEDLINE | ID: mdl-11919259

Subject(s)

ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism; Antineoplastic Agents, Phytogenic/pharmacokinetics; Cyclosporine/pharmacology; Enzyme Inhibitors/pharmacology; Paclitaxel/analogs & derivatives; Paclitaxel/pharmacokinetics; Taxoids; Administration, Oral; Antineoplastic Agents, Phytogenic/administration & dosage; Biological Availability; Cyclosporine/administration & dosage; Docetaxel; Drug Therapy, Combination; Enzyme Inhibitors/administration & dosage; Humans; Paclitaxel/administration & dosage

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Collection: 01-internacional Database: MEDLINE Main subject: Cyclosporine / Paclitaxel / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Taxoids / Enzyme Inhibitors / Antineoplastic Agents, Phytogenic Limits: Humans Language: En Journal: J Clin Oncol Year: 2002 Document type: Article Country of publication: United States

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