Non-covalent thrombin inhibitors featuring P(3)-heterocycles with P(1)-monocyclic arginine surrogates.

Reiner, John E; Siev, Daniel V; Araldi, Gian Luca; Cui, Jingrong Jean; Ho, Jonathan Z; Reddy, Komandla Malla; Mamedova, Lala; Vu, Phong H; Lee, Kuen Shan S; Minami, Nathaniel K; Gibson, Tony S; Anderson, Susanne M; Bradbury, Annette E; Nolan, Thomas G; Semple, J Edward

Reiner, John E; Siev, Daniel V; Araldi, Gian Luca; Cui, Jingrong Jean; Ho, Jonathan Z; Reddy, Komandla Malla; Mamedova, Lala; Vu, Phong H; Lee, Kuen Shan S; Minami, Nathaniel K; Gibson, Tony S; Anderson, Susanne M; Bradbury, Annette E; Nolan, Thomas G; Semple, J Edward.

Affiliation

Reiner JE; Department of Medicinal Chemistry, Corvas International, Inc., 3030 Science Park Road, San Diego, CA 92121, USA.

Bioorg Med Chem Lett ; 12(8): 1203-8, 2002 Apr 22.

Article in En | MEDLINE | ID: mdl-11934589

Subject(s)

Antithrombins/chemistry; Antithrombins/pharmacology; Arginine/chemistry; Heterocyclic Compounds/chemistry; Animals; Antithrombins/chemical synthesis; Dogs; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Arginine / Antithrombins / Heterocyclic Compounds Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2002 Document type: Article Affiliation country: United States

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