A practical synthesis and biological evaluation of 9-halogenated PGF analogues.

Tani, Kousuke; Naganawa, Atsushi; Ishida, Akiharu; Egashira, Hiromu; Odagaki, Yoshihiko; Miyazaki, Toru; Hasegawa, Tomoyuki; Kawanaka, Yasufumi; Sagawa, Kenji; Harada, Hiroyuki; Ogawa, Mikio; Maruyama, Takayuki; Nakai, Hisao; Ohuchida, Shuichi; Kondo, Kigen; Toda, Masaaki

Tani, Kousuke; Naganawa, Atsushi; Ishida, Akiharu; Egashira, Hiromu; Odagaki, Yoshihiko; Miyazaki, Toru; Hasegawa, Tomoyuki; Kawanaka, Yasufumi; Sagawa, Kenji; Harada, Hiroyuki; Ogawa, Mikio; Maruyama, Takayuki; Nakai, Hisao; Ohuchida, Shuichi; Kondo, Kigen; Toda, Masaaki.

Affiliation

Tani K; Minase Research Institute, Ono Pharmaceutical Co., Ltd., Shimamoto, Mishima, 618-8585, Osaka, Japan. k.tani@ono.co.jp

Bioorg Med Chem ; 10(6): 1883-94, 2002 Jun.

Article in En | MEDLINE | ID: mdl-11937346

Subject(s)

Halogens/chemistry; Prostaglandins F, Synthetic/chemical synthesis; Prostaglandins F, Synthetic/pharmacology; Animals; CHO Cells; Cricetinae; Crystallography, X-Ray; Cyclic AMP/metabolism; Molecular Conformation; Molecular Structure; Prostaglandins F, Synthetic/chemistry; Receptors, Prostaglandin E/metabolism; Second Messenger Systems/drug effects; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Prostaglandins F, Synthetic / Halogens Limits: Animals Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2002 Document type: Article Affiliation country: Japan

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