Premature aging in mice deficient in DNA repair and transcription.

de Boer, Jan; Andressoo, Jaan Olle; de Wit, Jan; Huijmans, Jan; Beems, Rudolph B; van Steeg, Harry; Weeda, Geert; van der Horst, Gijsbertus T J; van Leeuwen, Wibeke; Themmen, Axel P N; Meradji, Morteza; Hoeijmakers, Jan H J

de Boer, Jan; Andressoo, Jaan Olle; de Wit, Jan; Huijmans, Jan; Beems, Rudolph B; van Steeg, Harry; Weeda, Geert; van der Horst, Gijsbertus T J; van Leeuwen, Wibeke; Themmen, Axel P N; Meradji, Morteza; Hoeijmakers, Jan H J.

Affiliation

de Boer J; Medical Genetics Center, Department of Cell Biology and Genetics, Center for Biomedical Genetics, Erasmus University, 3000 DR Rotterdam, Netherlands.

Science ; 296(5571): 1276-9, 2002 May 17.

Article in En | MEDLINE | ID: mdl-11950998

Subject(s)

Aging, Premature/etiology; Aging; DNA Damage; DNA Helicases/physiology; DNA Repair; Proteins/physiology; Transcription Factors; Animals; Apoptosis; Bone Density; Cachexia/etiology; Crosses, Genetic; DNA Helicases/genetics; DNA-Binding Proteins/genetics; DNA-Binding Proteins/physiology; Female; Fertility; Gene Targeting; Growth Disorders/etiology; Growth Disorders/genetics; Hair Diseases/genetics; Kyphosis/etiology; Kyphosis/genetics; Kyphosis/pathology; Male; Mice; Mutation; Oxidative Stress; Phenotype; Point Mutation; Proteins/genetics; RNA-Binding Proteins/genetics; RNA-Binding Proteins/physiology; Transcription, Genetic; Xeroderma Pigmentosum Group A Protein; Xeroderma Pigmentosum Group D Protein

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Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / DNA Damage / Aging / Proteins / DNA Helicases / Aging, Premature / DNA Repair Type of study: Etiology_studies Limits: Animals Language: En Journal: Science Year: 2002 Document type: Article Affiliation country: Netherlands Country of publication: United States

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