Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein.

Wandel, Christoph; Kim, Richard; Wood, Margaret; Wood, Alastair

Wandel, Christoph; Kim, Richard; Wood, Margaret; Wood, Alastair.

Affiliation

Wandel C; Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee, USA.

Anesthesiology ; 96(4): 913-20, 2002 Apr.

Article in En | MEDLINE | ID: mdl-11964599

Subject(s)

ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism; Alfentanil/metabolism; Analgesics, Opioid/metabolism; Antidiarrheals/metabolism; Fentanyl/metabolism; Loperamide/metabolism; Morphine/metabolism; Sufentanil/metabolism; ATP Binding Cassette Transporter, Subfamily B, Member 1/antagonists & inhibitors; Alfentanil/pharmacology; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Fentanyl/pharmacology; Humans; Loperamide/pharmacology; Morphine/pharmacology; Sufentanil/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Alfentanil / Fentanyl / Sufentanil / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Analgesics, Opioid / Loperamide / Morphine / Antidiarrheals Limits: Animals / Humans Language: En Journal: Anesthesiology Year: 2002 Document type: Article Affiliation country: United States Country of publication: United States

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