Development of a combined protein and pharmacophore model for cytochrome P450 2C9.

de Groot, Marcel J; Alex, Alexander A; Jones, Barry C

de Groot, Marcel J; Alex, Alexander A; Jones, Barry C.

Affiliation

de Groot MJ; Department of Molecular Informatics, Structure & Design, Pfizer Global Research & Development, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent CT13 9NJ, U.K. degroot@sandwich.pfizer.com

J Med Chem ; 45(10): 1983-93, 2002 May 09.

Article in En | MEDLINE | ID: mdl-11985466

Subject(s)

Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System/chemistry; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases/chemistry; Amino Acid Sequence; Animals; Binding Sites; Crystallography, X-Ray; Cytochrome P450 Family 2; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidation-Reduction; Quantitative Structure-Activity Relationship; Quantum Theory; Rabbits; Sequence Alignment; Steroid 21-Hydroxylase/chemistry

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Collection: 01-internacional Database: MEDLINE Main subject: Steroid Hydroxylases / Aryl Hydrocarbon Hydroxylases / Cytochrome P-450 Enzyme System / Steroid 16-alpha-Hydroxylase Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2002 Document type: Article Affiliation country: United kingdom

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