C-terminal cyclization of an SDF-1 small peptide analogue dramatically increases receptor affinity and activation of the CXCR4 receptor.

Tudan, Christopher; Willick, Gordon E; Chahal, Sarabjit; Arab, Lakhdar; Law, Ping; Salari, Hassan; Merzouk, Ahmed

Tudan, Christopher; Willick, Gordon E; Chahal, Sarabjit; Arab, Lakhdar; Law, Ping; Salari, Hassan; Merzouk, Ahmed.

Affiliation

Tudan C; Chemokine Therapeutics Corporation Research Laboratories, 2386 East Mall, Suite 208, Vancouver, British Columbia, V6T 1Z3 Canada. tudanc@shaw.ca

J Med Chem ; 45(10): 2024-31, 2002 May 09.

Article in En | MEDLINE | ID: mdl-11985470

Subject(s)

Chemokines, CXC/chemistry; Lactams/chemical synthesis; Peptides, Cyclic/chemical synthesis; Receptors, CXCR4/metabolism; Amino Acid Sequence; Binding, Competitive; Cell Line; Chemokine CXCL12; Circular Dichroism; Humans; Lactams/chemistry; Lactams/pharmacology; Molecular Sequence Data; Peptides, Cyclic/chemistry; Peptides, Cyclic/pharmacology; Protein Structure, Secondary; Radioligand Assay; Receptors, CXCR4/agonists

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Peptides, Cyclic / Receptors, CXCR4 / Chemokines, CXC / Lactams Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2002 Document type: Article Country of publication: United States

Search on Google

Add to My VHL

XML

PubMed Links