Discovery and initial SAR of imidazoquinoxalines as inhibitors of the Src-family kinase p56(Lck).
Bioorg Med Chem Lett
; 12(10): 1361-4, 2002 May 20.
Article
in En
| MEDLINE
| ID: mdl-11992777
ABSTRACT
We have identified a novel series of 1,5-imidazoquinoxalines as inhibitors of Lck with excellent potency (IC50s<5 nM) as well as good cellular activity against T-cell proliferation (IC50s<1 microM). Structure-activity studies demonstrate the requirement for the core heterocycle in addition to an optimal 2,6-disubstituted aniline group.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Quinoxalines
/
Src-Family Kinases
/
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
/
Enzyme Inhibitors
/
Imidazoles
Limits:
Animals
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2002
Document type:
Article
Affiliation country:
United States