Identification of potent and selective oxytocin antagonists. Part 2: further investigation of benzofuran derivatives.

Wyatt, Paul G; Allen, Michael J; Chilcott, Josie; Gardner, Christopher J; Livermore, David G; Mordaunt, Jackie E; Nerozzi, Fabrizio; Patel, Mamta; Perren, Marion J; Weingarten, Gordon G; Shabbir, Shalia; Woollard, Patrick M; Zhou, Ping

Wyatt, Paul G; Allen, Michael J; Chilcott, Josie; Gardner, Christopher J; Livermore, David G; Mordaunt, Jackie E; Nerozzi, Fabrizio; Patel, Mamta; Perren, Marion J; Weingarten, Gordon G; Shabbir, Shalia; Woollard, Patrick M; Zhou, Ping.

Affiliation

Wyatt PG; Department of Medicinal Chemistry, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, Herts, UK.

Bioorg Med Chem Lett ; 12(10): 1405-11, 2002 May 20.

Article in En | MEDLINE | ID: mdl-11992787

Subject(s)

Benzofurans/chemical synthesis; Oxytocin/antagonists & inhibitors; Animals; Benzofurans/pharmacokinetics; Benzofurans/pharmacology; Drug Design; Female; Humans; Kinetics; Models, Molecular; Molecular Conformation; Rats; Receptors, Oxytocin/antagonists & inhibitors; Receptors, Oxytocin/metabolism; Structure-Activity Relationship; Uterine Contraction/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Benzofurans / Oxytocin Type of study: Diagnostic_studies Limits: Animals / Female / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2002 Document type: Article Affiliation country: United kingdom

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