A study of the substrate specificity of Na+-dependent and Na+-independent neutral amino acid transport systems in dog intestinal brush-border membrane vesicles using L-alanine analogues.

Hatanaka, Takahiro; Nabuchi, Yoshiaki; Ushio, Hidetoshi

Hatanaka, Takahiro; Nabuchi, Yoshiaki; Ushio, Hidetoshi.

Affiliation

Hatanaka T; Fuji Gotemba Research Laboratory, Chugai Pharmaceutical Co, Ltd, Shizuoka, Japan. hatanakatkh@chugai-pharm.co.jp

J Pharm Pharmacol ; 54(4): 549-54, 2002 Apr.

Article in En | MEDLINE | ID: mdl-11999133

Subject(s)

Alanine/pharmacokinetics; Amino Acid Transport Systems, Neutral/metabolism; Glycine/analogs & derivatives; Intestine, Small/metabolism; Microvilli/metabolism; Sodium Chloride/metabolism; Alanine/analogs & derivatives; Alanine/chemistry; Animals; Biological Transport, Active/drug effects; Carbon/metabolism; Carbon Radioisotopes/metabolism; Cell Membrane/drug effects; Cell Membrane/metabolism; Cytoplasmic Vesicles/metabolism; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors/pharmacokinetics; Glycine/chemistry; Glycine/pharmacokinetics; Intestine, Small/drug effects; Microvilli/drug effects; Phenylalanine/chemistry; Phenylalanine/pharmacokinetics; Potassium/metabolism; Potassium/pharmacology; Sodium Chloride/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Sodium Chloride / Amino Acid Transport Systems, Neutral / Alanine / Glycine / Intestine, Small / Microvilli Limits: Animals Language: En Journal: J Pharm Pharmacol Year: 2002 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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