Enzyme and plasma protein induction by multiple oral administrations of phenobarbital at a therapeutic dosage regimen in dogs.

Hojo, T; Ohno, R; Shimoda, M; Kokue, E

Hojo, T; Ohno, R; Shimoda, M; Kokue, E.

Affiliation

Hojo T; Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan.

J Vet Pharmacol Ther ; 25(2): 121-7, 2002 Apr.

Article in En | MEDLINE | ID: mdl-12000532

Subject(s)

Anticonvulsants/pharmacology; Anticonvulsants/pharmacokinetics; Cytochrome P-450 Enzyme System/biosynthesis; Cytochrome P-450 Enzyme System/drug effects; Dogs/metabolism; Microsomes, Liver/enzymology; Orosomucoid/drug effects; Phenobarbital/pharmacology; Phenobarbital/pharmacokinetics; Administration, Oral; Animals; Anticonvulsants/administration & dosage; Anticonvulsants/blood; Antipyrine/metabolism; Drug Administration Schedule; Enzyme Induction; Male; Microsomes, Liver/drug effects; Phenobarbital/administration & dosage; Phenobarbital/blood

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Collection: 01-internacional Database: MEDLINE Main subject: Phenobarbital / Orosomucoid / Microsomes, Liver / Cytochrome P-450 Enzyme System / Dogs / Anticonvulsants Limits: Animals Language: En Journal: J Vet Pharmacol Ther Year: 2002 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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