Evidence for protean agonism of RX 831003 at alpha 2A-adrenoceptors by co-expression with different G alpha protein subunits.

Pauwels, P J; Rauly, I; Wurch, T; Colpaert, F C

Pauwels, P J; Rauly, I; Wurch, T; Colpaert, F C.

Affiliation

Pauwels PJ; Centre de Recherche Pierre Fabre, Department of Cellular and Molecular Biology, 17, avenue Jean Moulin, 81106 Castres Cedex, France. peter.pauwels@pierre-fabre.com

Neuropharmacology ; 42(6): 855-63, 2002 May.

Article in En | MEDLINE | ID: mdl-12015212

Subject(s)

Adrenergic alpha-2 Receptor Agonists; Benzopyrans/pharmacology; Heterotrimeric GTP-Binding Proteins/biosynthesis; Imidazoles/pharmacology; Receptors, Adrenergic, alpha-2/biosynthesis; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists/metabolism; Adrenergic alpha-Antagonists/pharmacology; Animals; Benzopyrans/chemistry; Benzopyrans/metabolism; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate)/metabolism; Guanosine 5'-O-(3-Thiotriphosphate)/pharmacology; Humans; Imidazoles/chemistry; Imidazoles/metabolism; Receptors, Adrenergic, alpha-2/metabolism; Signal Transduction/drug effects; Signal Transduction/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Benzopyrans / Receptors, Adrenergic, alpha-2 / Heterotrimeric GTP-Binding Proteins / Adrenergic alpha-2 Receptor Agonists / Imidazoles Limits: Animals / Humans Language: En Journal: Neuropharmacology Year: 2002 Document type: Article Affiliation country: France Country of publication: United kingdom

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