Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis.

Pepys, M B; Herbert, J; Hutchinson, W L; Tennent, G A; Lachmann, H J; Gallimore, J R; Lovat, L B; Bartfai, T; Alanine, A; Hertel, C; Hoffmann, T; Jakob-Roetne, R; Norcross, R D; Kemp, J A; Yamamura, K; Suzuki, M; Taylor, G W; Murray, S; Thompson, D; Purvis, A; Kolstoe, S; Wood, S P; Hawkins, P N

Pepys, M B; Herbert, J; Hutchinson, W L; Tennent, G A; Lachmann, H J; Gallimore, J R; Lovat, L B; Bartfai, T; Alanine, A; Hertel, C; Hoffmann, T; Jakob-Roetne, R; Norcross, R D; Kemp, J A; Yamamura, K; Suzuki, M; Taylor, G W; Murray, S; Thompson, D; Purvis, A; Kolstoe, S; Wood, S P; Hawkins, P N.

Affiliation

Pepys MB; Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London NW3 2PF, UK. m.pepys@rfc.ucl.ac.uk

Nature ; 417(6886): 254-9, 2002 May 16.

Article in En | MEDLINE | ID: mdl-12015594

Subject(s)

Amyloidosis/drug therapy; Amyloidosis/metabolism; Serum Amyloid P-Component/metabolism; Amyloidosis/blood; Animals; Calcium/metabolism; Carboxylic Acids/chemistry; Carboxylic Acids/metabolism; Carboxylic Acids/pharmacology; Carboxylic Acids/therapeutic use; Cross-Linking Reagents/chemistry; Cross-Linking Reagents/metabolism; Cross-Linking Reagents/pharmacology; Cross-Linking Reagents/therapeutic use; Crystallography, X-Ray; Dimerization; Humans; Inhibitory Concentration 50; Liver/metabolism; Mice; Models, Molecular; Protein Binding; Protein Structure, Quaternary/drug effects; Pyrrolidines/chemistry; Pyrrolidines/metabolism; Pyrrolidines/pharmacology; Pyrrolidines/therapeutic use; Serum Amyloid P-Component/antagonists & inhibitors; Serum Amyloid P-Component/chemistry

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Collection: 01-internacional Database: MEDLINE Main subject: Serum Amyloid P-Component / Amyloidosis Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nature Year: 2002 Document type: Article Affiliation country: United kingdom

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