Altered tumor necrosis factor-alpha (TNF-alpha) processing in adipocytes and increased expression of transmembrane TNF-alpha in obesity.

Xu, Haiyan; Uysal, K Teoman; Becherer, J David; Arner, Peter; Hotamisligil, Gökhan S

Xu, Haiyan; Uysal, K Teoman; Becherer, J David; Arner, Peter; Hotamisligil, Gökhan S.

Affiliation

Xu H; Division of Biological Sciences, Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

Diabetes ; 51(6): 1876-83, 2002 Jun.

Article in En | MEDLINE | ID: mdl-12031976

Subject(s)

Adipocytes/metabolism; Gene Expression; Obesity/metabolism; Tumor Necrosis Factor-alpha/genetics; Tumor Necrosis Factor-alpha/metabolism; 3T3 Cells; ADAM Proteins; ADAM17 Protein; Adipose Tissue/metabolism; Adipose Tissue/ultrastructure; Adult; Animals; Antigens, CD/physiology; Cell Membrane/metabolism; Cells, Cultured; Humans; Immunosorbent Techniques; Metalloendopeptidases/genetics; Metalloendopeptidases/metabolism; Mice; Middle Aged; RNA, Messenger/analysis; Receptors, Tumor Necrosis Factor/deficiency; Receptors, Tumor Necrosis Factor/physiology; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II

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Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression / Tumor Necrosis Factor-alpha / Adipocytes / Obesity Type of study: Prognostic_studies Limits: Adult / Animals / Humans / Middle aged Language: En Journal: Diabetes Year: 2002 Document type: Article Affiliation country: United States

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