The long-term effect of dietary advice in men with coronary disease: follow-up of the Diet and Reinfarction trial (DART).
Eur J Clin Nutr
; 56(6): 512-8, 2002 Jun.
Article
in En
| MEDLINE
| ID: mdl-12032650
ABSTRACT
OBJECTIVE:
To assess the long-term effect of dietary advice on diet and mortality after a randomised trial of men with a recent history of myocardial infarction.DESIGN:
Questionnaire survey and mortality follow-up after a trial of dietary advice.SETTING:
Twenty-one hospitals in south Wales and south-west England.SUBJECTS:
Former participants in the Diet and Reinfarction Trial. MAIN OUTCOMEMEASURES:
Current fish intake and cereal fibre intake. All-cause mortality, stroke mortality and coronary mortality.RESULTS:
By February 2000, after 21147 person years of follow-up, 1083 (53%) of the men had died. Completed questionnaires were obtained from 879 (85%) of the 1030 men alive at the beginning of 1999. Relative increases in fish and fibre intake were still present at 10 y but were much smaller. The early reduction in all-cause mortality observed in those given fish advice (unadjusted hazard 0.70 (95% CI 0.54, 0.92)) was followed by an increased risk over the next 3 y (unadjusted hazard 1.31 (95% CI 1.01, 1.70). Fat and fibre advice had no clear effect on coronary or all-cause mortality. The risk of stroke death was increased in the fat advice group-the overall unadjusted hazard was 2.03 (95% CI 1.14, 3.63).CONCLUSIONS:
In this follow-up of a trial of intensive dietary advice following myocardial infarction we did not observe any substantial long-term survival benefit. Further trials of fish and fibre advice are feasible and necessary to clarify the role of these foods in coronary disease.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dietary Fats
/
Dietary Fiber
/
Seafood
/
Coronary Disease
/
Myocardial Infarction
Type of study:
Clinical_trials
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
Eur J Clin Nutr
Journal subject:
CIENCIAS DA NUTRICAO
Year:
2002
Document type:
Article
Affiliation country:
United kingdom