Conformations and receptor activity of desmopressin analogues, which contain gamma-turn mimetics or a psi[CH(2)O] isostere.

Hedenström, Mattias; Yuan, ZhongQing; Brickmann, Kay; Carlsson, Jolanta; Ekholm, Kjell; Johansson, Birgitta; Kreutz, Eva; Nilsson, Anders; Sethson, Ingmar; Kihlberg, Jan

Hedenström, Mattias; Yuan, ZhongQing; Brickmann, Kay; Carlsson, Jolanta; Ekholm, Kjell; Johansson, Birgitta; Kreutz, Eva; Nilsson, Anders; Sethson, Ingmar; Kihlberg, Jan.

Affiliation

Hedenström M; Organic Chemistry, Department of Chemistry, Umeå University, SE-901 87 Umeå, Sweden.

J Med Chem ; 45(12): 2501-11, 2002 Jun 06.

Article in En | MEDLINE | ID: mdl-12036358

Subject(s)

Deamino Arginine Vasopressin/analogs & derivatives; Deamino Arginine Vasopressin/chemical synthesis; Receptors, Vasopressin/drug effects; Renal Agents/chemical synthesis; Animals; Antidiuretic Hormone Receptor Antagonists; Deamino Arginine Vasopressin/chemistry; Deamino Arginine Vasopressin/pharmacology; Diuresis/drug effects; Dose-Response Relationship, Drug; Female; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Mimicry; Protein Structure, Secondary; Rats; Rats, Sprague-Dawley; Receptors, Vasopressin/agonists; Renal Agents/chemistry; Renal Agents/pharmacology; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Renal Agents / Receptors, Vasopressin / Deamino Arginine Vasopressin Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2002 Document type: Article Affiliation country: Sweden

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