Molecular mechanisms of nickel carcinogenesis.
Toxicol Lett
; 127(1-3): 69-75, 2002 Feb 28.
Article
in En
| MEDLINE
| ID: mdl-12052643
ABSTRACT
Humans are exposed to carcinogenic nickel (Ni) compounds both occupationally and environmentally. In this paper, molecular mechanisms of nickel carcinogenesis are considered from the point-of-view of the uptake of nickel sulfide particles in cells, their dissolution and their effects on heterochromatin. Molecular mechanisms by which nickel induces gene silencing, DNA hypermethylation and inhibition of histone acetylation, will be discussed.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carcinogens
/
Neoplasms
/
Nickel
Limits:
Animals
/
Humans
Language:
En
Journal:
Toxicol Lett
Year:
2002
Document type:
Article
Affiliation country:
United States