Interferon-alpha therapy following autologous peripheral blood stem cell transplantation for adult T cell leukemia/lymphoma.
Acta Haematol
; 107(4): 213-9, 2002.
Article
in En
| MEDLINE
| ID: mdl-12053149
ABSTRACT
In the present report, we describe a case of adult T cell leukemia/lymphoma (ATLL), a 58-year-old woman, successfully treated with interferon (IFN)-alpha following autologous peripheral blood stem cell transplantation (auto-PBSCT). The patient remains in remission with full performance status for more than 12 months. Auto-PBSCT reduced the abdominal lymphoma mass and IFN-alpha eliminated residual tumor cells, possibly through the induction of specific T-cell subsets expressing CD3, CD8 on their surfaces and either IFN-gamma or tumor necrosis factor (TNF)-alpha in cytoplasm. We have treated a total of 4 ATLL patients with auto-PBSCT, including the case presented herein. All other patients treated with auto-PBSCT were not followed by adjuvant chemotherapy or cytokine therapy and relapsed within 3 months after auto-PBSCT. This evidence suggests that the therapeutic success of the present case was attributable to the administration of IFN-alpha immunotherapy following auto-PBSCT.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Leukemia-Lymphoma, Adult T-Cell
/
Interferon-alpha
/
Hematopoietic Stem Cell Transplantation
Limits:
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Acta Haematol
Year:
2002
Document type:
Article
Affiliation country:
Japan