Phorbol 12-myristate 13-acetate up-regulates the transcription of MUC2 intestinal mucin via Ras, ERK, and NF-kappa B.

Lee, Hae-Wan; Ahn, Dae-Ho; Crawley, Suzanne C; Li, Jian-Dong; Gum, James R; Basbaum, Carol B; Fan, Nancy Q; Szymkowski, David E; Han, Sang-Young; Lee, Bong H; Sleisenger, Marvin H; Kim, Young S

Lee, Hae-Wan; Ahn, Dae-Ho; Crawley, Suzanne C; Li, Jian-Dong; Gum, James R; Basbaum, Carol B; Fan, Nancy Q; Szymkowski, David E; Han, Sang-Young; Lee, Bong H; Sleisenger, Marvin H; Kim, Young S.

Affiliation

Lee HW; Gastrointestinal Research Laboratory, Veterans Affairs Medical Center, San Francisco, California 94121, USA.

J Biol Chem ; 277(36): 32624-31, 2002 Sep 06.

Article in En | MEDLINE | ID: mdl-12077118

Subject(s)

Mitogen-Activated Protein Kinases/metabolism; Mucins/biosynthesis; NF-kappa B/metabolism; Tetradecanoylphorbol Acetate/pharmacology; Up-Regulation; ras Proteins/metabolism; Binding Sites; Cell Line; Cell Nucleus/metabolism; Colonic Neoplasms/genetics; Colonic Neoplasms/metabolism; Cyclic AMP-Dependent Protein Kinases/metabolism; Dose-Response Relationship, Drug; Enzyme Inhibitors/pharmacology; Genes, Dominant; Humans; Luciferases/metabolism; Models, Biological; Mucin-2; Mucins/genetics; Mutation; Promoter Regions, Genetic; Protein Kinase C/metabolism; RNA/metabolism; Signal Transduction; Time Factors; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Tetradecanoylphorbol Acetate / Up-Regulation / NF-kappa B / Ras Proteins / Mitogen-Activated Protein Kinases / Mucins Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2002 Document type: Article Affiliation country: United States Country of publication: United States

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