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BB rat lyp mutation and Type 1 diabetes.
Ramanathan, S; Poussier, P.
Affiliation
  • Ramanathan S; Arthritis and Immune Disorder Research Centre at the University Health Network, University of Toronto, Ontario, Canada.
Immunol Rev ; 184: 161-71, 2001 Dec.
Article in En | MEDLINE | ID: mdl-12086310
ABSTRACT
BioBreeding (BB) rats spontaneously develop an autoimmune diabetic syndrome similar to that observed in humans and NOD mice. One of the diabetes susceptibility loci maps to the lyp locus on chromosome 4. In this article we describe the consequences of the BB rat lyp mutation on T-cell homeostasis, repertoire and function, as well as its role in the pathogenesis of type I diabetes.
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Collection: 01-internacional Database: MEDLINE Main subject: Rats, Mutant Strains / Protein Tyrosine Phosphatases / Diabetes Mellitus, Type 1 Limits: Animals / Humans Language: En Journal: Immunol Rev Year: 2001 Document type: Article Affiliation country: Canada
Search on Google
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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Rats, Mutant Strains / Protein Tyrosine Phosphatases / Diabetes Mellitus, Type 1 Limits: Animals / Humans Language: En Journal: Immunol Rev Year: 2001 Document type: Article Affiliation country: Canada