Use of disease-modifying antirheumatic drugs in patients with psoriatic arthritis.
Joint Bone Spine
; 69(3): 275-81, 2002 May.
Article
in En
| MEDLINE
| ID: mdl-12102274
ABSTRACT
UNLABELLED Few prospective placebo-controlled studies have evaluated disease-modifying antirheumatic drugs (DMARDs) in the treatment of peripheral psoriatic arthritis. OBJECTIVE:
To evaluate second-line treatments used in clinical practice in patients with psoriatic arthritis.METHOD:
We studied a cross-section of 100 consecutive patients seen by hospital-based or office-based rheumatologists for psoriatic arthritis. PATIENTS The 55 men and 45 women had a mean age of 48 years (range, 17-79 years) and a mean disease duration of 7 years (range, 1-24 years).RESULTS:
The most commonly used DMARDs were sulfasalazine, gold, methotrexate, and hydroxychloroquine (64, 43, 41 et 17 patients, respectively). These drugs had been stopped because of inefficacy in 31%, 31%, 12%, and 53% of patients, respectively, and because of adverse events in 23%, 44%, 22%, and 41% of patients, respectively. At the time of the study, mean treatment durations were 15, 21, 34, and 12 months, respectively, and the drugs were still being used in 45%, 21%, 66%, and 6% of patients.CONCLUSION:
Our data confirm the value of methotrexate and salazopyrine. Methotrexate had the best risk/benefit ratio. Gold was often responsible for side effects. Hydroxychloroquine was inadequately effective and poorly tolerated.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sulfasalazine
/
Arthritis, Psoriatic
/
Methotrexate
/
Antirheumatic Agents
/
Glucosamine
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Joint Bone Spine
Journal subject:
REUMATOLOGIA
Year:
2002
Document type:
Article
Affiliation country:
France