Evidence of dual sites of action of dendrimers: SPL-2999 inhibits both virus entry and late stages of herpes simplex virus replication.

Gong, Yunhao; Matthews, Barry; Cheung, Dorothy; Tam, Teresa; Gadawski, Izabelle; Leung, Daniel; Holan, George; Raff, John; Sacks, Stephen

Gong, Yunhao; Matthews, Barry; Cheung, Dorothy; Tam, Teresa; Gadawski, Izabelle; Leung, Daniel; Holan, George; Raff, John; Sacks, Stephen.

Affiliation

Gong Y; Viridae Clinical Sciences, Inc., 1134 Burrard Street, Vancouver, BC, Canada V6Z 1Y8. gongyh@viridae.com

Antiviral Res ; 55(2): 319-29, 2002 Aug.

Article in En | MEDLINE | ID: mdl-12103432

Subject(s)

Antiviral Agents/pharmacology; Herpesvirus 1, Human/drug effects; Herpesvirus 2, Human/drug effects; Polymers; Virus Replication/drug effects; Animals; Chlorocebus aethiops; DNA, Viral/biosynthesis; DNA, Viral/drug effects; Herpes Simplex/virology; Herpesvirus 1, Human/pathogenicity; Herpesvirus 1, Human/physiology; Herpesvirus 2, Human/pathogenicity; Herpesvirus 2, Human/physiology; Humans; Macromolecular Substances; Microbial Sensitivity Tests; Vero Cells; Viral Plaque Assay

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Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Polymers / Virus Replication / Herpesvirus 2, Human / Herpesvirus 1, Human Limits: Animals / Humans Language: En Journal: Antiviral Res Year: 2002 Document type: Article Country of publication: Netherlands

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