Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI).

Miller, William H; Seefeld, Mark A; Newlander, Kenneth A; Uzinskas, Irene N; Burgess, Walter J; Heerding, Dirk A; Yuan, Catherine C K; Head, Martha S; Payne, David J; Rittenhouse, Stephen F; Moore, Terrance D; Pearson, Stewart C; Berry, Valerie; DeWolf, Walter E; Keller, Paul M; Polizzi, Brian J; Qiu, Xiayang; Janson, Cheryl A; Huffman, William F

Miller, William H; Seefeld, Mark A; Newlander, Kenneth A; Uzinskas, Irene N; Burgess, Walter J; Heerding, Dirk A; Yuan, Catherine C K; Head, Martha S; Payne, David J; Rittenhouse, Stephen F; Moore, Terrance D; Pearson, Stewart C; Berry, Valerie; DeWolf, Walter E; Keller, Paul M; Polizzi, Brian J; Qiu, Xiayang; Janson, Cheryl A; Huffman, William F.

Affiliation

Miller WH; GlaxoSmithKline Pharmaceuticals, 1250 South Collegeville Road, P.O. Box 5089, Collegeville, PA 19426, USA. william_h_miller@gsk.com

J Med Chem ; 45(15): 3246-56, 2002 Jul 18.

Article in En | MEDLINE | ID: mdl-12109908

Subject(s)

Acrylamides/chemical synthesis; Aminopyridines/chemical synthesis; Anti-Bacterial Agents/chemical synthesis; Enzyme Inhibitors/chemical synthesis; Fatty Acid Synthases/antagonists & inhibitors; Oxidoreductases/antagonists & inhibitors; Acrylamides/chemistry; Acrylamides/pharmacology; Aminopyridines/chemistry; Aminopyridines/pharmacology; Animals; Anti-Bacterial Agents/chemistry; Anti-Bacterial Agents/pharmacology; Crystallography, X-Ray; Databases, Factual; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Enzyme Inhibitors/chemistry; Enzyme Inhibitors/pharmacology; Fatty Acid Synthases/chemistry; Haemophilus influenzae/drug effects; Inhibitory Concentration 50; Microbial Sensitivity Tests; Models, Molecular; Oxidoreductases/chemistry; Rats; Staphylococcal Infections/drug therapy; Staphylococcus aureus/drug effects; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Oxidoreductases / Acrylamides / Enzyme Inhibitors / Fatty Acid Synthases / Aminopyridines / Anti-Bacterial Agents Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2002 Document type: Article Affiliation country: United States Country of publication: United States

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