CD11b+ neutrophils predominate over RAM11+ macrophages in stretch-injured muscle.
Muscle Nerve
; 25(6): 837-44, 2002 Jun.
Article
in En
| MEDLINE
| ID: mdl-12115972
ABSTRACT
The purpose of this study was to determine whether both neutrophils and macrophages infiltrate the hematoma site of stretch-injured rabbit tibialis anterior muscle. The Mab.198 antibody was used to detect CD11b(+) neutrophils or macrophages. Neutrophils were identified specifically by using the RPN3/57 antibody. The RAM11 antibody was used to detect macrophages. The histological characteristics of the hematoma site, torn fibers or inflammatory cells, were present primarily at 4 and 24 h, but not at 48 and 72 h after injury. A difference in the Mab.198(+) cellular concentration was detected over time between uninjured and injured muscles (P = 0.03). The injured-uninjured difference in the RPN3/57(+) or RAM11(+) cellular concentrations approached significance (P = 0.07) or else was deemed insignificant (P = 0.13), respectively. Therefore, neutrophils may predominate over RAM11(+) macrophages in stretch-injured muscle. These findings may influence the antiinflammatory strategies used to treat stretch injuries.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sprains and Strains
/
Macrophage-1 Antigen
/
Muscle, Skeletal
/
Macrophages
/
Neutrophils
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Muscle Nerve
Year:
2002
Document type:
Article
Affiliation country:
United States