The tandem repeated irritation test: a new method to assess prevention of irritant combination damage to the skin.
Acta Derm Venereol
; 82(2): 94-7, 2002.
Article
in En
| MEDLINE
| ID: mdl-12125960
ABSTRACT
The effect of a protective cream was tested in a new tandem repeated irritation test with tandem application of 0.5% sodium lauryl sulphate (SLS) and undiluted toluene. The irritants were applied twice daily for 30 min to the ventral forearms of 20 volunteers. Irritant cutaneous reactions were quantified by a visual score, transepidermal water loss, chromametry and skin capacitance. Concurrent application of SLS/toluene induced stronger reactions than those caused by twice daily application of each irritant on its own. A protective effect of the protective cream was obtained against all treatment combinations and was significant for SLS/SLS (p < or = 0.01) and SLS/ toluene (p < or = 0.05). Our results indicate that the tandem repetitive irritation test has great potential in the evaluation of skin care products to prevent irritant contact dermatitis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sodium Dodecyl Sulfate
/
Dermatitis, Irritant
/
Irritants
Type of study:
Diagnostic_studies
/
Etiology_studies
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Acta Derm Venereol
Year:
2002
Document type:
Article
Affiliation country:
Germany